The range of developments discussed in NPR’s Up First newsletter highlights how diplomacy, public health, and technology policy are moving at the same time across multiple regions. In Washington, President Trump and administration officials are said to be calibrating public expectations about possible steps toward an end to the Iran war, while Iranian officials continue to lay out how they view the sequencing of any agreement.

In the newsletter’s account, Iran has not issued an official response to a proposed outline, but semi-official reports point to disagreements over “one or two” issues as a reason the potential deal could be at risk. After Trump spoke Saturday with leaders of several Gulf countries and with Israel, he said the U.S. and Iran have “largely negotiated” a memorandum of understanding intended to reopen the Strait of Hormuz.

NPR reports that Trump then shifted his tone on Sunday in a series of social media posts, saying the U.S. would not rush into an agreement. On the Iranian side, Esmaeil Baghaei, Iran’s foreign ministry spokesman, said that if a deal is reached, nuclear discussions with the U.S. would commence over a 60-day period, and NPR further reports that Hossein Nooshabadi said that 60-day period would start after a 30-day initial agreement regarding the Strait.

NPR’s Mara Liasson, speaking to listeners on Up First, said Iran is firmly rejecting any discussions regarding its nuclear program, and she described Republicans as being critical of the possibility of a deal among some lawmakers who supported the strike on Iran. She also tied the diplomacy debate to domestic politics, saying a deal could help Republicans in upcoming elections while noting Democrats’ relative advantage in generic ballot settings and the continued unpopularity of the Democratic brand in competitive districts.

Sen. Lindsey Graham also urged Trump to pursue a deal that matches what he called strength, with Liasson relaying Graham’s call for Trump to “stick to your guns in getting a good deal with Iran.” NPR’s Aya Batrawy said the U.S. has made clear that Iran would need to start allowing ships to pass through the Strait as part of the deal, while Batrawy also reported Iran’s demands including unfreezing U.S. funds in foreign banks and ending Israel’s war in Lebanon against Iran-backed Hezbollah.

Batrawy said Gulf Arab states have been heavily affected by the war and that the scale of current regional risks has increased pressure to avoid a return to conflict, including by noting that around 2 million pilgrims are performing the hajj in Saudi Arabia. She said there is increasing urgency for an agreement because the war does not appear to have softened Iran’s stance.

Separately, the newsletter’s coverage points to a worsening crisis in the Democratic Republic of Congo, where NPR reports that the latest figures from the Congolese government show more than 200 people have died in the Ebola outbreak. NPR says health workers have registered more than 900 suspected cases and that the virus is spreading rapidly across eastern Congo, a region described as larger than Florida, while the World Health Organization warns the risk of spread across the country is very high.

NPR’s Emmet Livingstone said ongoing battles between armed groups and national armies are complicating efforts to contain the disease, and she described four different national armies fighting on the ground. Livingstone said the biggest conflict involves the Rwanda-backed M23 rebels and that while some cases of the virus have been confirmed in the area, aid groups are struggling with distrust in healthcare, historical issues and misinformation, along with a critical shortage of PPE and medical supplies.

The newsletter also reported a public-safety incident in Garden Grove, California, where about 50,000 residents were said to remain under evacuation orders as emergency response teams worked at the GKN Aerospace manufacturing plant. NPR said firefighters found a potential crack in a tank late Saturday and quoted Orange County Fire Division Chief Craig Covey describing a crack as a potentially “good outcome,” while noting that the tank contains about 7,000 gallons of methyl methacrylate, which NPR described as a highly toxic and flammable chemical used to make resins and plastics.

At the Vatican, Pope Leo XIV addressed the rise of artificial intelligence in his first encyclical, described as a teaching addressed to the world’s 1.4 billion Catholics. NPR’s Claire Giangrave said the pope urged engagement in shaping AI ethics rather than leaving that work to wealthy tech elites, describing the development of AI as a new Industrial Revolution and framing data exploitation as a new form of colonialism.

Giangrave reported that the pope called it “one of the most urgent moral challenges of our time” and argued that governments and international organizations must step up to place laws and regulations around AI use. She also said some AI companies resist regulation while others seek guidance from religious traditions as they navigate changes brought by the technology.

The newsletter concluded with other items, including what it called heightened U.S. attention to “Church and State,” a new series planned by NPR exploring religion’s influence on government, and entertainment coverage that discussed CBS’s scheduling changes for a comedy show hosted by Byron Allen.